The detailed chemical structure of a single molecule has been imaged for the first time, say researchers.
The physical shape of single carbon nanotubes has been outlined before, using similar techniques – but the new method even shows up chemical bonds.
Understanding structure on this scale could help in the design of many things on the molecular scale, particularly electronics or even drugs.
The IBM researchers report their findings in the journal Science.
It is the same group that in July reported the feat of measuring the charge on a single atom.
In both cases, a team from IBM Research Zurich used what is known as an atomic force microscope or AFM.
Their version of the device acts like a tiny tuning fork, with one of the prongs of the fork passing incredibly close to the sample and the other farther away.
When the fork is set vibrating, the prong nearest the sample will experience a minuscule shift in the frequency of its vibration, simply because it is getting close to the molecule.
Comparing the frequencies of the two prongs gives a measure of just how close the nearer prong is, effectively mapping out the molecule’s structure.
The measurement requires extremes of precision. In order to avoid the effects of stray gas molecules bounding around, or the general atomic-scale jiggling that room-temperature objects experience, the whole setup has to be kept under high vacuum and at blisteringly cold temperatures.
However, the tip of the AFM’s prong is not well-defined and isn’t necessarily sharp on the scale of single atoms. The effect of this bluntness is to blur the instrument’s images.
The researchers have now hit on the idea of deliberately picking up just one small molecule – made of one atom of carbon and one of oxygen – with the AFM tip, forming the sharpest, most well-defined tip possible.
Their measurement of a pentacene molecule using this carbon monoxide tip shows the bonds between the carbon atoms in five linked rings, and even suggests the bonds to the hydrogen atoms at the molecule’s periphery….