Cases of split foot malformation, Africa, [October 2006] | (source) (info)
Case of hand polydactyly | Dermatology Online Journal (link)
Triphalangeal Thumb | Dermatology Online Journal (link)
Ectrodactyly or split hand/foot malformation (SHFM) or cleft hand, central ray deficiency (previously called “lobster-claw malformation”). | Dermatology Online Journal (link)
The less you understand about biology and genetics, the more shocking deformities can be. Sometimes there are human causes for human deformities: pollution, drugs, etc.
Thalidomide is a sedative–hypnotic, and multiple myeloma medication. The drug is a potent teratogen in rabbits and primates including humans: this means that severe birth defects may result if the drug is taken during pregnancy.
Thalidomide was developed by German pharmaceutical company Grünenthal in Stolberg (Rhineland) near Aachen. It was sold from 1957 to 1961 in almost 50 countries under at least 40 names … chiefly sold and prescribed during the late 1950s and early 1960s to pregnant women, as an antiemetic to combat morning sickness and as an aid to help them sleep. Before its release, inadequate tests were performed to assess the drug’s safety, with catastrophic results for the children of women who had taken thalidomide during their pregnancies.
… Thalidomide is racemic – it contains both left- and right-handed isomers in equal amounts. The (R) enantiomer is effective against morning sickness. The (S) is teratogenic and causes birth defects. The enantiomers can interconvert in vivo – that is, if a human is given pure (R)-thalidomide or (S)-thalidomide, both isomers can be found in the serum – therefore, administering only one enantiomer will not prevent the teratogenic effect in humans. The mechanism of its biological action is being debated, with current literature that suggests that it intercalates into DNA in G–C rich regions. –wiki
Microwave ovens create different isomers of safe molecules, which is why I never nuke my food. I still got this horrible flu, however.
Dr. Lita Lee of Hawaii reported in the December 9, 1989 Lancet:
“Microwaving baby formulas converted certain trans-amino acids into their synthetic cis-isomers. Synthetic isomers, whether cis-amino acids or trans-fatty acids, are not biologically active.
Further, one of the amino acids, L-proline, was converted to its d-isomer, which is known to be neurotoxic (poisonous to the nervous system) and nephrotoxic (poisonous to the kidneys). – mercola