Root cause of inflammatory diseases discovered – Times Of India

By | January 2, 2013

Root 2A ‘constant cloud’ of potent inflammatory molecules surrounding the cells responsible for diseases such as thickening of the arteries and rheumatoid arthritis, has been discovered.

The findings by the scientists at the University of East Anglia (UEA) could eventually lead to new treatments for chronic inflammatory diseases.

Cardiovascular disease arising from atherosclerosis (thickening of the arteries) kills around 17 million people worldwide each year, including 120,000 people in England and Wales, while rheumatoid arthritis affects around 400,000 people in the UK.

The team studied a type of white blood cell called monocytes.

Monocytes play an important role in the human immune system and help protect our bodies against infection. But they can also invade tissue, triggering the early stages of common inflammatory diseases.

The researchers detected for the first time that monocytes were surrounded by a constant cloud.

This cloud was found to be made up of potent inflammatory molecules called adenosine triphosphate, or ATP. Further study showed that the ATP molecules were being propelled through the cell wall by the actions of lysosomes.

Lysosomes are sub-cellular compartments within blood cells, which had previously been thought to only break down cell waste.

“These unexpected findings shed light on the very early stages in the development of inflammatory diseases such as atherosclerosis and rheumatoid arthritis,” lead author Dr Samuel Fountain of UEA’s School of Biological Sciences, said.

“We found that lysosomes are actually highly dynamic and play a key role in the way inflammatory cells function. This is an exciting development that we hope will lead to the discovery of new targets for inflammatory drugs in around five years and potential new treatments beyond that,” Dr Fountain said.

He said that further study was now needed to investigate how to control the release of ATP by lysosomes in monocytes and other white blood cells, and to understand how inflammation may be affected in patients with inherited diseases involving lysosomes.

The study was published recently online by The Journal of Cell Science.

http://articles.timesofindia.indiatimes.com/2012-07-05/health/32550845_1_rheumatoid-arthritis-blood-cells-inflammatory-diseases

I’m still trying to understand inflammation and what to do about it.

Suggestions I’ve read (see Mercola.com and NaturalNews.com) include: get enough sun, cut out the carbs, stop eating trans fats, eat more saturated fats, drink fluoride free mineral rich water, eat more fermented foods such as sauerkraut, and sleep on an electrically grounded sheet.

3 thoughts on “Root cause of inflammatory diseases discovered – Times Of India

  1. EverythingZija

    Reblogged this on Everything Zija and commented:
    Zija has 46 anti-inflammatories, 23 vitamins and minerals, and all amino acids. Great results with no side effects. All-natural and kosher.

  2. arjay001

    Get enough sun! Yeah, I know that being in the dark, wet and cold or the north was murder for joint/muscle pain. Since beng in Texas, my pain level has decreased by at least 50% or more. I think there is a relationship between chronic inflammation and type 2 diabetes. A lot can be said for diet and exercise.

  3. Fred Killer

    ATP and ADP are a fundamental part of muscular energy production so perhaps a lack of exercise leaves excessive quantities of unused ATP in the tissues that ultimately break down in another, more destructive way, instead of being turned into ADP in the muscles?

    The way I see it, we’re still mammals like any other and millions of years of evolution and challenges have given us a body that not only benefits from regular, strenuous exercise but absolutely requires it for optimum health.

    As the old saying goes, “Use it or lose it!”

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